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Leiomyoma

MedGen UID:
9710
Concept ID:
C0023267
Neoplastic Process
Synonyms: Fibroid; Fibroid Tumor; Fibroid Tumors; Fibroids; Fibromyoma; Fibromyomas; Leiomyomas; Tumor, Fibroid; Tumors, Fibroid
SNOMED CT: Fibromyoma (1162890002); Leiomyofibroma (1162890002); Plexiform leiomyoma (1162890002); Fibroleiomyoma (1162890002); Fibroid (1162890002); Leiomyoma (1162890002); Soft tissue tumor of smooth muscle differentiation (1187125003); Leiomyomatous neoplasm (1187125003)
 
Monarch Initiative: MONDO:0001572

Definition

A well-circumscribed benign smooth muscle neoplasm characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeiomyoma

Professional guidelines

PubMed

Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128

Recent clinical studies

Etiology

Qu Y, Chen L, Guo S, Liu Y, Wu H
Front Endocrinol (Lausanne) 2023;14:1133260. Epub 2023 Jul 27 doi: 10.3389/fendo.2023.1133260. PMID: 37576957Free PMC Article
Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:3-11. Epub 2017 Oct 1 doi: 10.1016/j.bpobgyn.2017.09.004. PMID: 29054502
Laughlin-Tommaso SK
J Minim Invasive Gynecol 2018 Feb;25(2):229-236. Epub 2017 Aug 15 doi: 10.1016/j.jmig.2017.08.642. PMID: 28821471
McWilliams MM, Chennathukuzhi VM
Semin Reprod Med 2017 Mar;35(2):181-189. Epub 2017 Mar 9 doi: 10.1055/s-0037-1599090. PMID: 28278535Free PMC Article
Tyagi N, Tyagi R, Griffin Y
BMJ Case Rep 2014 Dec 4;2014 doi: 10.1136/bcr-2014-207763. PMID: 25477364Free PMC Article

Diagnosis

Rosland TE, Kleist BA, Halvorsen M, Goderstad JM
Tidsskr Nor Laegeforen 2024 Jun 25;144(8) Epub 2024 Jun 12 doi: 10.4045/tidsskr.23.0818. PMID: 38934324
Lumsden MA, Hamoodi I, Gupta J, Hickey M
BMJ 2015 Oct 13;351:h4887. doi: 10.1136/bmj.h4887. PMID: 26463991
Arleo EK, Schwartz PE, Hui P, McCarthy S
AJR Am J Roentgenol 2015 Oct;205(4):912-21. doi: 10.2214/AJR.14.13946. PMID: 26397344
Sultana R, Humayun S
J Coll Physicians Surg Pak 2015 Apr;25(4):294-5. PMID: 25899198
Pastor Navarro H, Martínez Ruiz J, Martínez Sanchíz C, Perán Teruel M, Segura Martín M, Pastor Guzman JM, Virseda Rodríguez J
Arch Esp Urol 2013 Oct;66(8):820-3. PMID: 24136487

Therapy

Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
Lonnerfors C
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:113-119. Epub 2017 Sep 29 doi: 10.1016/j.bpobgyn.2017.09.005. PMID: 29103894
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209Free PMC Article

Prognosis

Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Yuan H, Zhang S
Arch Gynecol Obstet 2019 Jan;299(1):47-53. Epub 2018 Dec 5 doi: 10.1007/s00404-018-4991-2. PMID: 30519753
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170
Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Davis GB, Blanchard DK, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):401-11. doi: 10.1007/s002689910065. PMID: 10706912

Clinical prediction guides

Mension E, Carmona F, Vannuccini S, Chapron C
Fertil Steril 2024 Jul;122(1):12-19. Epub 2024 May 9 doi: 10.1016/j.fertnstert.2024.05.003. PMID: 38729337
Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article

Recent systematic reviews

Akhatova A, Aimagambetova G, Bapayeva G, Laganà AS, Chiantera V, Oppelt P, Sarria-Santamera A, Terzic M
Int J Environ Res Public Health 2023 Mar 2;20(5) doi: 10.3390/ijerph20054480. PMID: 36901489Free PMC Article
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Somigliana E, Reschini M, Bonanni V, Busnelli A, Li Piani L, Vercellini P
Reprod Biomed Online 2021 Jul;43(1):100-110. Epub 2021 Mar 23 doi: 10.1016/j.rbmo.2021.03.013. PMID: 33903032
Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R
BJOG 2017 Sep;124(10):1501-1512. Epub 2017 May 13 doi: 10.1111/1471-0528.14640. PMID: 28296146
Pritts EA, Parker WH, Olive DL
Fertil Steril 2009 Apr;91(4):1215-23. Epub 2008 Mar 12 doi: 10.1016/j.fertnstert.2008.01.051. PMID: 18339376

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